Reassessment of the experimental skin permeability coefficients of polycyclic aromatic hydrocarbons and organophosphorus pesticides

Human exposure to polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides (OPPs) by dermal route is a continuing concern in environmental occupational toxicology. Diverse authors have measured vitro the absorption flux permeability coefficient (kP) of those compounds delivered on skin surface using volatile solvents. However, there isn’t harmonized method obtain kP when test substance deposited as solid. Consequently, varied experimental kPs been reported for PAHs OPPs, most clear disagreement with values predicted well-established mathematical models. In this work, we collected permeation fluxes these toxicants through human calculated (aqueous) based maximum water solubility. The reanalyzed recalculated show improved consistency between different works Notably, benzo[a]pyrene, among others, was approximately 100 times higher than it had previously considered. Suggestions are given generalize studies other solvent-deposited drugs.